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rinkeДата: Четверг, 06.03.2014, 00:39 | Сообщение # 16
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mbarntinДата: Среда, 12.03.2014, 08:51 | Сообщение # 17
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fmyykjfДата: Пятница, 13.02.2015, 12:56 | Сообщение # 18
Группа: Гости





Tacrolimus (also FK-506 or fujimycin, selling names Prograf, Advagraf, Protopic) is an immunosuppressive pharmaceutical that is most of all used after allogeneic organ displace to trim down the activity of the patient's vaccinated approach and so bring the danger of organ rejection. It is also utilized in a up to date preparation in the treatment of atopic dermatitis (eczema), dictatorial refractory uveitis after bone marrow transplants, exacerbations of tiniest change blight, and the fleece prepare vitiligo.
It is a 23-membered macrolide lactone discovered in 1984 from the fermentation stock of a Japanese befoul test that contained the bacteria Streptomyces tsukubaensis. It reduces interleukin-2 (IL-2) production during T-cells.
Dead letter
Tacrolimus was discovered in 1984; it was among the opening macrolide immunosuppressants discovered, preceded at near the disclosure of rapamycin (sirolimus) on Rapa Nui (Easter Islet) in 1975.<> - It is produced during a breed of stain bacterium,Streptomyces tsukubaensis.<> - The reputation tacrolimus is derived from 'Tsukuba macrolide immunosuppressant'.<> -
Tacrolimus was first approved during the Commons and Cure-all Supplying (FDA) in 1994 in compensation make use of in liver transplantation; this has been extended to number kidney, heart, small bowel, pancreas, lung, trachea, overlay, cornea, bone marrow, and limb transplants.
Availability
The branded manifestation of the medicine is owned close to Astellas Pharma, and is sold below the marketing names Prograf noted twice common,Advagraf, a sustained launch formulation allowing aeons ago daily dosing, and Protopic (Eczemus in Pakistan past Brookes Pharma), the up to date formulation.<> - Advagraf is to hand in 0.5, 1, 3 and 5 mg capsules, the correct is concentrations of 0.1% and 0.03%.
A jiffy once-daily formulation of tacrolimus is in Phase 3 clinical trials in the U.S. and Europe. This formulation also has a smoother pharmacokinetic limn gross that reduces the peak-to-trough rank in blood levels compared to twice-daily tacrolimus.<> - Materials from the primary Phase 3 contest in steady kidney shift patients showed that this once-daily formulation was non-inferior in efficacy and sanctuary compared to twice-daily tacrolimus.<> - A next Condition 3 litigation in de novo patients is ongoing.<> -
Mechanism of strength
Tacrolimus is chemically known as a macrolide. In T-cells, activation of the T-cell receptor normally increases intracellular calcium, which acts via calmodulin to actuate calcineurin. Calcineurin then dephosphorylates the transcription element NF-AT (atomic agent of activated T-cells), which moves to the nucleus of the T-cell and increases the activity of genes coding to save IL-2 and common cytokines. Tacrolimus prevents the dephosphorylation of NF-AT.<> - In detachment, Tacrolimus reduces peptidyl-prolyl isomerase operation via binding to the immunophilin FKBP12 (FK506 binding protein) creating a up to date complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocytesignal transduction and IL-2 transcription.<> - Although this action is correspond to to ciclosporin, studies from shown that the degree of acute also brush is reduced nearby tacrolimus capitalize on done with ciclosporin.<>0 - Although short-term immunosuppression as regards submissive and scion survival is institute to be similar between the two drugs, tacrolimus results in a more favorable lipid good, and this may eat urgent long-term implications fact the prognostic act upon of rejection on implant survival.<>1 -
From http://www.fmyykj.com - suzhou pharmaceutical technology co.,ltd.
 
famuyiyaohДата: Понедельник, 23.02.2015, 16:26 | Сообщение # 19
Группа: Гости





Moxidectin (Milbemycin B<> - ) kills parasites, so is acclimated to instead of the restraining and control of heartworm and intestinal worms, and can be organize in treatments prescribed in behalf of animals such as dogs, cats, horses, steers and sheep. Industriousness methods in the service of moxidectin alternate before treatment, and include voiced, superficial, and injectable solutions. Cydectin Spew out On is a barter name after a formulation in compensation use on cattle and red deer.
Moxidectin is a semisynthetic imitative of nemadectin <> - which is produced during fermentation at near Streptomyces cyano-griseus. This Streptomyces species was discovered in a excrement cross-section from Australia in the past due 1980s at ease alongside an agronomist working in the direction of the American Cyanamid company.
Moxidectin treats and controls some of the most unrefined internal and apparent parasites by selectively binding to parasites’ glutamate-gated chloride ion channels. These channels are needed to the function of invertebrate balls and muscle cells; when moxidectin binds to the channels, it disrupts neurotransmission, resulting in paralysis and expiration of the parasite.
Studies of moxidectin demonstrate the side effects change by animal and may be fake beside the product’s formulation, appositeness method and dosage. The products are mainly recommended about a veterinarian to ensure correct speak and application. Herding dogs may be avermectin-sensitive, but avermectin-sensitive dogs can tolerate standard doses after heartworm prevention. Moxidectin is evidently harmless after collie breeds. As a heartworm preventative, moxidectin can be injected in a minute every six months call of the brand tag Proheart6, or every 12 months answerable to the trade-mark name Proheart SR 12.
Moxidectin is the referred to of a trial to assess its suitability, as an alternate to ivermectin, to treat onchocerciasis in humans.<> -

From http://www.fmyykj.com - suzhou pharmaceutical technology co.,ltd.
 
MichaeltyncДата: Среда, 25.02.2015, 21:31 | Сообщение # 20
Группа: Гости





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tcsindustrykДата: Среда, 04.03.2015, 12:54 | Сообщение # 21
Группа: Гости





Docetaxel (as generic or tipsy the shoppers high regard Taxotere) is a clinically set anti-mitotic chemotherapy medication (medication which interferes with apartment compartmentation). It is hand-me-down in general payment the treatment of knocker, ovarian, prostate, and non-small room lung cancer.<> - <> - <> - Docetaxel has an FDA approved allege representing treatment of patients who possess locally advanced, or metastatic breast or non small-cell lung cancer who partake of undergone anthracycline-based chemotherapy and failed to stop cancer chain or relapsed<> - and a European subscribe to payment work in hormone-refractory prostate cancer.<> -
According to a 2005 article in the journal Drugs, docetaxel administered as a one-hour infusion every three weeks commonly over a ten cycle despatch, docetaxel is considered as or more compelling than doxorubicin, paclitaxel and fluorouracil as a cytotoxic agent.<> - Extent the effectiveness of docetaxel versus paclitaxel and other taxanes is quiescent controversial. Individual more recent articles be suffering with set up "no sign that regimens containing docetaxel yield greater benefits than those including paclitaxel."<> - Additionally, the optimal scheduling of docetaxel and other taxanes remains unconfirmed. A three-week dispensation list utilized to be and is until now considered effective but hip studies are indicating a weekly register influence be better. A 2010 article in Prevailing Clinical Pharmacology states, "weekly administration has emerged as the optimal schedule." Docetaxel is marketed worldwide under the name Taxotere nearby Sanofi-Aventis.<> - Annual sales in 2010 were Euro 2.122 billion ($US 3.1 billion). The evident expired in 2010.<citation>
Constitution
Docetaxel is of the chemotherapy knock out bearing; taxane, and is a semi-synthetic analogue of paclitaxel (Taxol), an quotation from the bark of the rare Pacific yew tree Taxus brevifolia.<> - Owed to paucity of paclitaxel, extensive research was carried out primary to the formulation of docetaxel – an esterified artefact of 10-deacetyl baccatin III, which is extracted from the renewable and agreeably present European yew tree.
Docetaxel differs from paclitaxel at two positions in its chemical structure. It has a hydroxyl useful coterie on carbon 10, whereas paclitaxel has an acetate ester, and a tert-butyl carbamate ester exists on the phenylpropionate side string as an alternative of the benzyl amide in paclitaxel. The carbon 10 functional organize mutation causes docetaxel to be more water soluble than paclitaxel.<> -
Formulations and compositions
Docetaxel is a white coat capacity and is the strenuous ingredient available in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in polysorbate 80.<> - <> - The mixing is a clear brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL.<> - 20 mg Taxotere is distributed in a blister carton containing chestnut single-dose vial of Taxotere (docetaxel) preparation in 0.5 mL infecund pyrogen-free anhydrous polysorbate 80, and a distinct portion Taxotere creditworthy vial containing 1.5 mL 13% ethanol in saline to be combined and diluted in a 250 mL infusion bag containing 0.9% sodium chloride or 5% glucose in the interest administration.<> - 80 mg Taxotere is supplied identically but with 2.0 mL polysorbate 80 and 6.0 mL 13% ethanol in saline. The docetaxel and financially sound vials are combined to pay a colloidal suspension of 10 mg/mL and the required dispense is drawn from this solution. Vials be suffering with an overfill to compensate on liquid harm during preparation, foaming, adhesion to vial walls and the numb volume. 20 mg vials may be stored in the service of 24 months in this world 25 °C away from understanding and 80 mg vials since 26 months in the same conditions.<> -
Recently Sanofi has got sanction in behalf of one-vial formulation.<citation>needed - With this one-vial formulation, the preparation of the infusion infusion is simplified during eliminating the blue ribbon dilution step. The two-vial and one-vial formulations in the unchanged panacea point, docetaxel trihydrate, and the word-for-word excipients (ethanol, polysorbate 80 and citric acid). The one-vial formulation is administered as an aqueous intravenous solution that contains the same tranquillizer theme in the unchanged concentration as the already approved two-vial formulation. The unmodified level, quality, and measure of polysorbate 80 are closest in the infusion solution of both formulations. The at best argument between these two formulations is the sum of ethanol.
From http://www.tcsindustry.com - TCS INDUSTRY LTD
 
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